Friday, April 7:  PM
 

2:00 – 7:00 PM

Workshop Registration    Victoria Conference Centre

6:00 - 8:00 PM

Welcoming Reception

Fairmont Empress Hotel, Palm Court/Crystal Ballroom

Saturday, April 8:  AM
 

8:20 – 8:35 AM

OPENING REMARKS:  R. Bouillon, A.W. Norman
 

Session I:  VDR and Gene Regulation A – Session Chairpersons:  C. Carlberg, M.R. Haussler

8:35 – 8:55 AM
8:55 – 9:00 AM

S. Kato
Discussion

Ligand-Induced Transrepression Mechanism by Nuclear Receptor through Chromatin Remodeling/Modification Complexes
 

9:00 – 9:10 AM
9:10 – 9:15 AM

S. Kim
Discussion

Multiple Enhancer Regions at Significant Distances Upstream of the Transcriptional Start Site Mediate Rankl Gene Expression in Response to 1,25-Dihydroxyvitamin D₃
 

9:15 – 9:35 AM
9:35 – 9:40 AM

D. Moras
Discussion

Structural Basis for the Control of VDR Function in Transcription Regulation
 

9:40 – 9:50 AM
9:50 – 9:55 AM

L.A. Zella
Discussion

Enhancers Located in the Vitamin D Receptor Gene Mediate Transcriptional Autoregulation by 1,25-Dihydroxyvitamin D₃   
 

9:55 – 10:10 AM

COFFEE BREAK

Session II:  Chemistry and Structure-Function A – Session Chairpersons:  A. Mourino, G. Posner

10:10 – 10:30 AM
10:30 – 10:35 AM

G.H. Posner
Discussion

Novel Hybrid Analogs of Calcitriol With Unconventional 1-Substituents  and Potentiating Side-Chains
 

10:35 – 10:45 AM
10:45 – 10:50 AM

M.T. Mizwicki
Discussion

On How the Structure-Function Results of 1,25D Side-Chain Metabolites Can Be Potentially Understood by a VDR Two Pocket Molecular Model
 

10:50 – 11:10 AM
11:10 – 11:15 AM

P. DeClercq
Discussion

Creative Synthesis of Novel Vitamin D Analogs for Health and Disease
 

Session III: Poster Session A
 

11:15 – 1:30 PM

Saturday, April 8:  PM

Session IV: Cancer A – Session Chairpersons:  D. Feldman, C. Johnson

1:30 – 1:50 PM
1:50 – 1:55 PM

J.E. Welsh
Discussion

Vitamin D Signaling in Mammary Gland: What Have We Learned?
 

1:55 – 2:05 PM
2:05 – 2:10 PM

M.J. Larriba
Discussion

The Inhibition of WNT/b-Catenin Signaling By 1a,25-Dihydroxyvitamin D₃ Is Abrogated by Snail1 and Restored
by Ectopic VDR Expression in Colon Cancer Cells

2:10 – 2:30 PM
2:30 – 2:35 PM

H.P. Koeffler
Discussion

1,25-Dihydroxy Vitamin D₃ and its Analogs in Leukemia and Innate Immunity

2:35 – 2:45 PM
2:45 – 2:50 PM

I. Chung
Discussion

Epigenetic Silencing of CYP24 in Tumor-Derived Endothelial Cells (TDEC) Contributes to Selective Growth Inhibition by Calcitriol

2:50 – 3:10 PM
3:10 – 3:15 PM

D. Feldman
Discussion

Calcitriol Regulation of Diverse Target Genes Provides Multiple Pathways for Inhibition of Prostate Cancer Cell Growth 

3:15 – 3:35 PM

COFFEE BREAK

Session V: Kidney - Actions – Session Chairperson: D. Bikle

3:35 – 3:55 PM
3:55 – 4:00 PM

H.S. Tenenhouse
Discussion

Phosphate Transport: Molecular Basis, Regulation and Pathophysiology 

4:00 – 4:20 PM
4:20 – 4:25 PM

R. Kumar
Discussion

The Phosphatonins and the Regulation of Phosphate Transport and Vitamin D Metabolism 

Session VI: Vitamin D Nutrition Aspects A – Session Chairpersons:  R. Mason, R. Bouillon

4:25 – 4:45 PM
4:45 – 4:50 PM

E. Giovannucci
Discussion

Predictors of Vitamin D Status and Cancer Incidence and Mortality 

4:50 – 5:30 PM
5:30 – 5:40 PM

B.A. Gilchrest
Discussion

PLENARY LECTURE: Sun Protection and Vitamin D: Three Dimensions of Obfuscation

Sunday, April 9:  AM

8:15 – 8:30 AM

Young Investigator Awards Ceremony

Session VII: VDR and Gene Regulation B – S. Christakos

8:30 – 8:50 AM
8:50 – 8:55 AM

J.W. Pike
Discussion

Vitamin D Receptor-Regulated Enhancers Located at Diverse Sites Within Target Genes Function Both to Modify Chromatin Structure and As Recruitment Centers for RNA Polymerase II

8:55 – 9:05 AM
9:05 – 9:10 AM

Y. Oda
Discussion

Differential Role of Two VDR Coactivators, DRIP205 and SRC3, in Keratinocyte Proliferation and Differentiation
 

9:10 – 9:30 AM
9:30 – 9:35 AM

C. Carlberg
Discussion

How Does the Vitamin D Receptor Recognize Its Chromatin Targets?
 

9:35 – 9:45 AM
9:45 – 9:50 AM

S. Peleg
Discussion

The Importance of Nuclear Import in Protection of the Vitamin D Receptor (VDR) from Ubiquitination and Proteasome-Mediated Degradation
 

9:50 – 10:00 AM
10:00 – 10:05 AM

Y. Yamamoto
Discussion

A Tissue-Specific Function by Unliganded Nuclear Receptor

 

10:05 – 10:20 AM

COFFEE BREAK
 

Session VIII: Structure-Function B – Session Chairpersons:  J.C. Fleet, P. De Clercq
 

10:20 – 10:40 AM
10:40 – 10:45 AM

H.F. Deluca
Discussion

The Use of Selected Analogs of 1a,25-Dihydroxyvitamin D₃ to Delineate the Functions of Vitamin D
 

10:45 – 10:55 AM
10:55 – 11:00 AM

R. Masuyama
Discussion

Partial VDR Rescue in Intestine Reverses Impaired Bone Mineralization of VDR Null Mice
 

11:00 – 11:20 AM
11:20 – 11:25 AM

A. Kittaka
Discussion

Creative Synthesis of Novel Vitamin D Analogs for Health and Disease
 

Session IX: Poster Session B
 

11:25 PM – 1:30 PM

Sunday, April 9:  PM
 

Session X: Immunology – Session Chairpersons:  L. Adorini, C. Mathieu

1:30 – 2:00 PM
2:00 – 2:05 PM

R. Modlin
Discussion

TLR2/1 Induction of a Vitamin D Dependent Antimicrobial Response is Related to Skin Pigmentation
 

2:05 – 2:15 PM
2:15 – 2:20 AM

A.R. Martineau
Discussion

Vitamin D Enhances Antimycobacterial Immunity in vivo and in vitro
 

2:20 – 2:40 PM
2:40 – 2:45 PM

C. Mathieu
Discussion

Novel Insights in the Immune Function of the Vitamin D System
 

2:45 – 2:55 PM
2:55 – 3:00 PM

F. Szeto
Discussion

Increased NF-kB Activity in Fibroblasts Lacking the Vitamin D Receptor
 

3:00 PM – 3:20 PM

COFFEE BREAK

Sunday, April 9:  PM
 

Session XI: Vitamin D Hydroxylases and Metabolism – Session Chairpersons: H.L. Henry, M. Hewison

 
In Memory of John L. Omdahl and E. Barbara Mawer

3:20 – 3:40 PM
3:40 – 3:45 PM

M. Hewison
Discussion

Extra-Renal 25-Hydroxyvitamin D₃-1a-Hydroxylase in Human Health and Disease

3:45 – 3:55 PM
3:55 – 4:00 PM

A. Dusso
Discussion

PTH/cAMP-Induced 1,25-Dihydroxyvitamin D (1,25D)-C/EBPb Interactions Mediate 1,25D Tight Transcriptional Control of Renal 1,25D Production 

4:00 – 4:10 PM
4:10 – 4:15 PM

R. Bland
Discussion

Calcium Sensing Receptor-Mediated Regulation of 25-Hydroxyvitamin D₃-1a-Hydroxylase Activity in Human Proximal Tubule Cell Line

4:15 – 4:25 PM
4:25 – 4:30 PM

G.S. Reddy
Discussion

Metabolism of 1a,25 Dihydroxy-16-ene-20-Epi-Vitamin D₃ and its C-3 Epimer through a Novel C-1 Esterification Pathway in Rat Osteosarcoma Cells (UMR 106) 

4:30 – 4:40 PM
4:40 – 4:45 PM

N. Isoherran
Discussion

Identification of Human UDP-Glucuronosyltransferases Catalyzing Hepatic 1a,25-Dihydroxyvitamin D₃ Conjugation

4:45 – 4:55 PM
4:55 – 5:00 PM

J.R. Muindi
Discussion

CYP24 Splicing Variants Are Associated With Different Patterns of Constitutive and Calcitriol-Inducible CYP24 Activities in a Human Prostate Cancer Cells 

5:00 – 5:10 PM
5:10 – 5:15 PM

M.J. Rowling
Discussion

Megalin Mediated Endocytosis of Vitamin D Binding Protein Correlates with 25-Hydroxyvitamin D₃ Actions in Mammary Cells 

5:15 – 5:30 PM

Career Awards Ceremony

Monday, April 10:  AM

Session XII: Transgenic Models – Session Chairperson:  M.B. Demay

8:15 – 8:35 AM
8:35 – 8:40 AM

D. Goltzman
Discussion

New Concepts of Vitamin D Action As Illuminated By Transgenic Mice
 

Session XIII: Vitamin D Nutrition Aspects B – Session Chairpersons:  S. Whiting, P. Lips

8:40 – 9:20 AM
9:20 – 9:30 AM

R.P. Heaney
Discussion

PLENARY LECTURE: The Case for Improving Vitamin D Status

9:30 – 9:40 AM
9:40 – 9:45 AM

S.M. Kimball
Discussion

Dosing with the Upper Limit for Vitamin D₃ Intake Has No Effect on Serum Calcium or Calcitriol Levels in School Children 

9:45 – 10:05 AM
10:05 – 10:10 AM

R. Horst
Discussion

The Assessment of Circulating 25(OH)D and 1,25(OH)₂D: Where We Are and Where We Are Going 

10:10 – 10:30 AM

COFFEE BREAK

                                    Session Chairpersons:  A.W. Norman, R. Bouillon 

10:30 – 10:50 AM
10:50 – 10:55 AM

P. Lips
Discussion

Vitamin D Intake and Nutritional Status in Europe and Asia 

10:55 – 11:15 AM
11:15 – 11:20 AM

S.J. Whiting
Discussion

Dietary Intakes of Vitamin D in North America and In Asia-Pacific Countries Are Not Sufficient to Prevent Vitamin D Insufficiency 

11:20 – 11:30 AM
11:30 – 11:35 AM

A. Shao
Discussion

Review of Vitamin D Safety: Revision of the Tolerable Upper Intake Level (UL) 

11:35 – 11:45 AM
11:45 – 11:50 PM

B.W. Hollis
Discussion

Circulating Vitamin D₃ and 25(OH)D in Humans: An Important Tool to Define Adequate Nutritional Vitamin D Status 

11:50 – 12:00 PM
 

R. Vieth 

Summary of the North American Conference on UV, Vitamin D and Health

12:00 – 12:40 PM 

OPEN FORUM

FREE AFTERNOON

Tuesday, April 11:  AM

Session XIV: Renal Osteodystrophy – Session Chairperson: E. Slatopolsky, R. Thadhani

 
In Memory of Jack W. Coburn

8:15 – 8:35 AM
8:35 – 8:40 AM

A.J. Brown
Discussion

Secondary Hyperparathyroidism and Vitamin D Analogs: What Does the Future Hold?

8:40 – 8:50 AM
8:50 – 8:55 AM

M.V. Arcidiacono
Discussion

TGFa/EGFE-Induction of Dominant Negative C/EBPB (LIP) Mediates the Severity of Parathyroid Hyperplasia and the Onset of Vitamin D Resistance in Chronic Kidney Disease
 

8:55 – 9:15 AM
9:15 – 9:20 AM

R. Thadhani
Discussion

Vitamin D and Survival on Hemodialysis 

9:20 – 9:30 AM
9:30 – 9:35 AM

Y. Liu
Discussion

Therapeutic Role of Vitamin D Receptor Activator in Renal Interstitial Fibrosis in Mice
 

9:35 – 9:50 AM

COFFEE BREAK

Session XV: Rapid Responses – Session Chairperson: B. Boyan, A.W. Norman

9:50 – 10:10 AM
10:10 – 10:15 AM

B.D. Boyan
Discussion

1a,25(OH)₂D₃ Is an Autocrine Regulator of ECM Turnover and Growth Factor Release Via ERP60 Activated Matrix Vesicle MMPS
 

10:15 – 10:35 AM
10:35 – 10:40 AM

A.W. Norman
Discussion

1a,25(OH)₂D₃, Nucleus, Genomic Responses, Caveolae, Rapid Responses, Vitamin D Receptor WT and KO: Integration via a Conformational Ensemble Model
 

10:40 – 10:50 AM
10:50 – 10:55 AM

K.M. Dixon
Discussion

In Vivo Relevance for Photoprotection by the Vitamin D Rapid Response Pathway
 

Session XVI: Hair – Session Chairperson: R. Kumar
 

10:55 – 11:15 AM
11:15 – 11:20 AM

M.B. Demay
Discussion

Role of the Vitamin D Receptor in Hair Follicle Biology
 

Session XVII: Poster Session C
 

11:20 – 1:30 PM

Tuesday, April 11: PM
 

Session XVIII: Cancer B – Session Chairpersons:  D.L. Trump, G. Studzinski

1:30 – 1:50 PM
1:50 – 1:55 PM

L. Adorini
Discussion

Control of Prostate Growth and Inflammation by the Vitamin D Receptor Agonists BXL-628
 

1:55 – 2:05 PM
2:05 – 2:10 PM

M.J. Campbell
Discussion

Identifying 1a,25(OH)₂D₃-Responsive Transcriptional Profiles
 

2:10 – 2:20 PM
2:20 – 2:25 PM

M.F. Holick
Discussion

Evaluation of Novel Gemini Vitamin D Analogs for the Treatment of Colon, Prostate and Pancreatic Cancers
 

2:25 – 2:45 PM
2:45 – 2:50 AM

T.M. Beer
Discussion

Targeting the Vitamin D Receptor with High Dose Pulse Calcitriol 
 

2:50 – 3:00 PM
3:00 – 3:05 PM

C. Johnson
Discussion

Calcitriol Enhances Anti-Tumor Activity of Ketoconazole/Dexamethasone in vitro and in vivo in Human Prostate Cancer PC-3 Model Through Caspase-8/Caspase 6 and Mitochondrial/AIF Apoptotic Pathways
 

3:05 – 3:15 PM
3:15 – 3:20 PM

P.P. Dwivedi
Discussion

Role of Oncoprotein Growth Factor Independent-1 (GFI1) in Repression of 25-Hydroxyvitamin D 1-alpha Hydroxylase (CYP27B1) Gene In Human Prostate Cancer Cells
 

3:20 – 3:35 PM

COFFEE BREAK

Session XIX: Bone – Session Chairpersons:  J.P.T.M. van Leeuwen, H.F. Deluca

3:35 – 3:55 PM
3:55 – 4:00 PM

N. Kurihara
Discussion

Enhanced Vitamin D Receptor-Mediated Signal Transduction Appears to Be Requested for Development of Pagetic Osteoclasts
 

4:00 – 4:10 PM
4:10 – 4:15 PM

P.H. Anderson
Discussion

Autocrine Activities of 1a,25(OH)₂D₃ in Human Osteoblast-like Cells

4:15 – 4:35 PM
4:35 – 4:40 PM

P.T.M. van Leeuwen

TRPV Calcium Channels, Vitamin D and Bone Metabolism

Session XX: Skin-Heart - Session Chairperson:  M. Garabedian

4:40 – 5:00 PM
5:00 – 5:05 PM

D. Bikle
Discussion

Sequential Regulation of Keratinocyte Differentiation By 1,25(OH)₂D₃, VDR and Its Coregulators

5:05 – 5:15 PM
5:15 – 5:20 PM

R. Simpson
Discussion

Characterization of Heart Function and Structure in the Vitamin D Receptor Knockout Mouse

7:00 – 10:00 PM

Grand Banquet at the Royal BC Museum

Wednesday, April 12: AM
 

Session XXI: Osteoporosis – Session Chairpersons:  J.C. Gallagher, N. Kubodera

8:30 – 8:50 AM
8:50 – 8:55 AM

T. Matsumoto
Discussion

ED-71, A New Active Vitamin D, Increases Bone Mass Regardless of Serum 25(OH)D Levels in Osteoporotic Subjects

8:55 – 9:15 AM
9:15 – 9:20 AM

H. Bischoff-Ferrari
Discussion

Estimation of Optimal Serum 25-Hydroxyvitamin D Levels for Multiple Health Outcomes

9:20 – 9:30 AM
9:30 – 9:35 AM

J.C. Gallagher
Discussion

An Age Related Decrease in Creatine Clearance is Associated with an Increase in Number of Falls in Untreated Women but Not Women Receiving Calcitriol

9:35 – 9:55 AM

COFFEE BREAK

Session XXII: VDR and Gene Regulation B – Session Chairpersons: J.H. White, J.W. Pike

9:55 – 10:15 AM
10:15 – 10:20 AM

M.R. Haussler
Discussion

1,25-Dihydroxyvitamin D₃ (1,25D) and Fibroblast Growth Factor-23 (FGF-23), Inextricably Linked Reciprocal Endocrine Partners in the Regulation of Phosphate and Bone Metabolism

10:20 – 10:30 AM
10:30 – 10:35 AM

J.H. White
Discussion

Genomic Approaches to Identification of 1,25-Dihydroxyvitamin D₃ Target Genes Implicated in its Anticancer Properties

10:35 – 10:45 AM
10:45 – 10:50 AM

L. Verlinden
Discussion

1a,25-Dihydroxyvitamin D₃-Induced Down-Regulation of the Checkpoint Proteins, CHEK1 and CLASPIN, is Mediated by the Pocket Proteins p107 and P130

10:50 – 11:10 AM
11:10 – 11:15 AM

S. Christakos
Discussion

New Insights into the Function and Regulation of Vitamin D Target Proteins

11:15 – 11:25 AM
11:25 – 11:30 AM

H.D. Marks
Discussion

Transgenic Expression of the Human Vitamin D Receptor (VDR) in Duodenum of VDR-Null Mice Attenuates Age-Dependent Decline in Calcium Absorption

11:30 – 11:40 AM
11:40 – 11:45 AM

P. Dhawan
Discussion

Novel Regulation by Glucocorticoids of 25-Hydroxyvitamin D₃ 24-Hydroxylase (24(OH)ASE) Through A Functional Interaction Between GR and C/EBP Beta 

11:45 – 11:55 AM
11:55 – 12:00 AM

Z. Zhang
Discussion

Renal Protective Role of Vitamin D in the Development of Diabetic Nephropathy

12:00 – 12:10 PM        CLOSING REMARKS: R. Bouillon, A.W. Norman